Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

Emerg Infect Dis. 2021 Apr 2;27(5). doi: 10.3201/eid2705.204912. Online ahead of print.ABSTRACTThe dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.PMID:33797393 | DOI:10.3201/eid2705.204912

Source: Emerging Infectious Diseases - April 2, 2021 Category: Infectious Diseases Authors: Natalia Fintelman-Rodrigues Aline P D da Silva Monique Cristina Dos Santos Felipe B Saraiva Marcelo A Ferreira Jo ão Gesto Danielle A S Rodrigues Andr é M Vale Isaclaudia G de Azevedo Vin ícius C Soares Hui Jiang Hongdong Tan Diogo A Tschoeke Carolina Source Type: research