Saponin-adjuvanted recombinant vaccines containing rCP00660, rCP09720 or rCP01850 proteins against Corynebacterium pseudotuberculosis infection in mice

CONCLUSION: rCP01850 added by saponin was able to protect efficiently mice against C. pseudotuberculosis challenge, and to induce high IgG, IFN-γ and TNF-α levels. In spite of rCP00660 and rCP09720 had not same adequate protection levels, significant IgG, IFN-γ, and IL-17 levels and further studies aiming to improve protection rates should be conducted.PMID:33814234 | DOI:10.1016/j.vaccine.2021.03.062

Source: Vaccine - April 5, 2021 Category: Allergy & Immunology Authors: Francisco Silvestre Brilhante Bezerra Mara Thais de Oliveira Silva Andrea de F átima Silva Rezende Angela Sena Lopes Rodrigo Barros de Pinho Fabiana Kommling Seixas Tiago Veiras Collares Ricardo Wagner Dias Portela Vasco Ariston de Carvalho Azevedo Sibel Source Type: research