The Editors ’ Choice

Some food allergies (peanut, shellfish, and tree nuts) tend to persist for a lifetime in the majority of patients, implying a perpetual risk of accidental allergic reactions that can be life-threatening. Persistence of food allergies is driven by reactivation of immunologic memory, which restores the formation of pathogenic allergen-specific IgE. The precise requirements for the reactivation of memory IgE responses, however, remain poorly defined. In this issue, Bruton et  al (p 1381) assessed the requirement of IL-4Rα signaling for reactivation of allergic memory.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: The Editors ’ Choice Source Type: research