NIH scientists develop breath test for methylmalonic acidemia

(NIH/National Human Genome Research Institute) Researchers at the National Institutes of Health have developed a breath test that measures how well patients with methylmalonic acidemia (MMA) respond to receiving liver or combined liver and kidney transplantation.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

Related Links:

AbstractBackground and objective The main objective was to evaluate the impact of Hepatitis C Virus treatment with direct-acting antiviral agents on tacrolimus blood levels in recipients of kidney and heart allografts.Method We analysed Hepatitis C Virus infected adult patients who received tacrolimus as immunosuppressive maintenance therapy and received direct-acting antiviral agents treatment in a tertiary hospital with solid transplant multidisciplinary program in Madrid, Spain. Liver and renal function, tacrolimus dose and blood levels were analysed before and 12  weeks after the end of treatment.Results We identi...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
Purpose of review Accumulating evidence supports the important contribution of volume-related metrics to morbidity and mortality in patients receiving chronic haemodialysis. The purpose of this review is to summarize recent advances in the understanding and management of volume status in this high-risk group. Recent findings Delivery of optimal volume management involves three key components: accurate estimation of volume status, correction of extracellular fluid overload and prevention of intradialytic instability. The lack of a gold standard for assessing volume status makes accurate estimation difficult to achieve;...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: DIALYSIS AND TRANSPLANTATION: Edited by David J. Cohen Source Type: research
Fewer than 25 simultaneous heart-liver-kidney transplants (SHLKTxs) have been performed in the U.S. This highly complex operation was performed nine times by only four centers from 2018 to 2019. However, one institution, the University of Chicago Medical Center (UCMC), is responsible for two-thirds of all SHLKTxs performed in that period. There is a paucity of literature regarding the logistics and infrastructure of performing SHKLTxs. The development of a standardized, effective protocol would improve outcomes in the high-risk patients who undergo this operation.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 455 Source Type: research
Initial trials looking at the efficacy of kidney (KT) and liver transplantation (LT) in HIV-infected patients showed early graft and patient survival outcomes comparable to those in noninfected patients, except for patients with HCV co-infection. We hypothesized comparable long-term outcomes in the post-HCV direct acting agent (DAA) era.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Transplantation and tissue engineering Source Type: research
Publication date: Available online 28 September 2020Source: IDCasesAuthor(s): L. Carmans, A. Van Craenenbroeck, K. Lagrou, C.M. Deroose, X. Sagaert, A. Wolthuis, E. Van Wijngaerden, D.R. Kuypers
Source: IDCases - Category: Infectious Diseases Source Type: research
Publication date: Available online 28 September 2020Source: Hepatobiliary &Pancreatic Diseases InternationalAuthor(s): Peng-Peng Zhang, Xing-Guo She, Ke Cheng, Hong Liu, Ying Niu, Ying-Zi Ming
Source: Hepatobiliary and Pancreatic Diseases International - Category: Gastroenterology Source Type: research
Hepatitis E viral infection recently emerges as a global health concern. Over the last decade, the understanding of hepatitis E virus (HEV) had changed with the discovery of new genotypes like genotype-7 and genotype-8 with associated host and mode of infection. Diversification in the mode of hepatitis E infection transmission through blood transfusion, and organ transplants in contrast to classical feco-oral and zoonotic mode is the recent medical concern. The wide spectrum of infection ranging from self-limiting to acute liver failure is now overpowered by HEV genotype-specific chronic infection especially in transplant ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
No abstract available
Source: Transplantation - Category: Transplant Surgery Tags: Letters to the Editor Source Type: research
CONCLUSIONS: Our data suggest that minimization of CNI and conversion of CNI to mTOR inhibitors along with judicious use of prophylactic steroids may allow for the safe use of ICIs in SOT recipients with advanced cSCC. Short-term efficacy appears promising but prospective studies with further follow-up and a standardized protocol for prophylactic steroids are needed. IMPLICATIONS FOR PRACTICE: Solid organ transplant (SOT) recipients are at increased risk of developing malignancy due to long-term post-transplant immunosuppression. Although immune checkpoint inhibitors (ICI) are increasingly shown to be successful in tr...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Oncologist Source Type: research
More News: Biology | Kidney Transplant | Kidney Transplantation | Liver | Liver Transplant | National Institutes of Health (NIH) | Transplants | Urology & Nephrology