The role of microRNAs in modulating SARS-CoV-2 infection in human cells: a systematic review

In conclusion, despite the limited number of studies identified, based on the search terms and eligibility criteria applied, this systematic review provides evidence on the impact of miRNAs on SARS-CoV-2 infection and COVID-19. Although most of the reported viral/host miRNAs interactions were based on in silico prediction analysis, they demonstrate the relevance of the viral/host miRNA interaction for viral activity and host responses. In addition, the identified studies highlight the potential use of miRNAs as therapeutic targets against COVID-19, and other viral human diseases (This review was registered at the International Prospective Register of Systematic Reviews (PROSPERO) database (#CRD42020199290).PMID:33812037 | DOI:10.1016/j.meegid.2021.104832
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Source Type: research