Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways

CONCLUSIONS: Our study suggests that higher levels of genomic instability are associated with more advanced disease in esophageal adenocarcinoma. Furthermore, CDKN2A, KRAS, and SMAD4 represent prognostic biomarkers, given their strong association with poor survival.PMID:33795256 | DOI:10.1158/1078-0432.CCR-20-4707

Source: Clinical Cancer Research - April 2, 2021 Category: Cancer & Oncology Authors: Smita Sihag Samuel C Nussenzweig Henry Walch Meier Hsu Kay See Tan Francisco Sanchez-Vega Walid K Chatila Sergio A De La Torre Assem Patel Yelena Y Janjigian Steven B Maron Geoffrey Y Ku Laura H Tang Jaclyn F Hechtman Pari M Shah Abraham J Wu David R Jone Source Type: research