A Pan-Histone Deacetylase Inhibitor Enhances the Antitumor Activity of B7-H3-specific CAR-T Cells in Solid Tumors

CONCLUSIONS: Our results show that our novel strategy which combines SAHA and B7-H3.CAR-T cells enhances their therapeutic efficacy with solid cancers and justify its translation to a clinical setting.PMID:33811153 | DOI:10.1158/1078-0432.CCR-20-2487

Source: Clinical Cancer Research - April 3, 2021 Category: Cancer & Oncology Authors: Xinyuan Lei Zhanpeng Ou Zhaohui Yang Jianglong Zhong Yanliang Zhu Jing Tian Jiannan Wu Heran Deng Xinyu Lin Yu Peng Bowen Li Lile He Zhiming Tu Weixiong Chen Qunxing Li Niu Liu Hanqing Zhang Zhangsong Wang Zezhen Fang Teppei Yamada Xiaobin Lv Tian Tian Gu Source Type: research