Ignoring a basic pathophysiological mechanism of heart failure progression will not make it go away

Am J Physiol Heart Circ Physiol. 2021 Apr 2. doi: 10.1152/ajpheart.00105.2021. Online ahead of print.ABSTRACTA link between heart failure (HF) and low thyroid hormone (TH) function has been known for over a century. Nonetheless, there is a general belief that TH treatment of HF patients may not be worth the risk. This is largely based on two clinical trials where heart patients were treated with excessive doses of TH analogs, not actual THs. Further complicating the issue is the fact that normalization of THs in non-cardiac patients can often be challenging. This issue is not going away as noted by a steady increase in TH-HF citations in recent years. In this article, we discuss what we know and how we may move the field forward.PMID:33797271 | DOI:10.1152/ajpheart.00105.2021
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Source Type: research