Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs

CONCLUSION: These results show that the human three dimensional ex vivo model effectively reflects the in vivo processes in damaged human liver (viral, alcoholic, nonalcoholic steatohepatitis liver diseases) and provides the proof of concept that the LS examined model permits a rapid evaluation of new anti-fibrotic therapies when used alone or in combination.PMID:33708350 | PMC:PMC7934011 | DOI:10.4254/wjh.v13.i2.187

Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Daria Kartasheva-Ebertz Jesintha Gaston Loriane Lair-Mehiri Pierre-Philippe Massault Olivier Scatton Jean-Christophe Vaillant Vladimir Alexei Morozov Stanislas Pol Sylvie Lagaye Source Type: research