Piecing the fragments together: Dynamical insights into the enhancement of BRD4-BD1 (BET protein) druggability in cancer chemotherapy using novel 8-methyl-pyrrolo[1,2-a]pyrazin-1(2H)-one derivatives

CONCLUSION: Conclusively, the design of highly potent therapeutics could be facilitated by the incorporation of pharmacologically active small molecule fragments into the scaffold of existing drugs.PMID:33749556 | DOI:10.2174/1389201022666210322122056

Source: Current Pharmaceutical Biotechnology - March 22, 2021 Category: Biotechnology Authors: Oluwole B Akawa Opeyemi S Soremekun Fisayo A Olotu Mahmoud E S Soliman Source Type: research