FGFR Inhibitors in Elderly Patients with Advanced Biliary Tract Cancer: An Unsolved Issue

Expert Rev Gastroenterol Hepatol. 2021 Mar 31. doi: 10.1080/17474124.2021.1911646. Online ahead of print.ABSTRACTBackgroundDespite recent advances in the understanding of the molecular landscape of biliary tract cancer (BTC), advanced disease continues to carry a poor prognosis, and the benefit from systemic treatments remains modest. However, BTCs have emerged as malignancies harboring specific potentially-druggable aberrations, and thus, several molecularly targeted treatments have been recently tested. Among these, fibroblast growth factor receptor (FGFR) inhibitors have shown interesting results in previously treated BTC patients with advanced diseaseAreas coveredIn this review, we aimed to provide an overview of available evidence on FGFR inhibitors in elderly patients with metastatic BTC, especially focusing on subgroup analyses of recently published trials exploring this novel therapeutic approach in these aggressive malignancies.Expert opinionThe FGFR1, FGFR2, and FGFR3 inhibitor pemigatinib has been recently approved by the United States Food and Drug Administration (FDA) in metastatic BTCs harboring FGFR2 fusion or other rearrangement. However, few data are available regarding the use of FGFR inhibitors in elderly BTCs, a patient population that remains seriously under-represented in clinical trials.PMID:33787429 | DOI:10.1080/17474124.2021.1911646
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research