Differential Induction of Allergen-specific IgA Responses following Timothy Grass Subcutaneous and Sublingual Immunotherapy

Capsule summary: Local and systemic induction of IgA following SLIT represents a distinct immunologic mechanism compared to SCIT. IgA to grass pollen and IgE and IgG4 to grass pollen components allowed participant stratification according to treatment group and response.

Source: Journal of Allergy and Clinical Immunology - April 2, 2021 Category: Allergy & Immunology Authors: Mohamed H. Shamji, David Larson, Aarif Eifan, Guy W. Scadding, Tielin Qin, Kaitie Lawson, Michelle L. Sever, Ellen Macfarlane, Janice A. Layhadi, Peter A. W ürtzen, Rebecca V. Parkin, Srinath Sanda, Kristina M. Harris, Gerald T. Nepom, Alkis Togias, Step Source Type: research