Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations

Genetic studies in underrepresented populations identify disproportionate numbers of novel associations. However, most genetic studies use genotyping arrays and sequenced reference panels that best capture variation most common in European ancestry populations. To compare data generation strategies best suited for underrepresented populations, we sequenced the whole genomes of 91 individuals to high coverage as part of the Neuropsychiatric Genetics of African Population-Psychosis (NeuroGAP-Psychosis) study with participants from Ethiopia, Kenya, South Africa, and Uganda.

Source: The American Journal of Human Genetics - March 25, 2021 Category: Genetics & Stem Cells Authors: Alicia R. Martin, Elizabeth G. Atkinson, Sin éad B. Chapman, Anne Stevenson, Rocky E. Stroud, Tamrat Abebe, Dickens Akena, Melkam Alemayehu, Fred K. Ashaba, Lukoye Atwoli, Tera Bowers, Lori B. Chibnik, Mark J. Daly, Timothy DeSmet, Sheila Dodge, Abebaw F Tags: Article Source Type: research