Optical Measurements of Sweat for in Vivo Quantification of CFTR Function in Individual Sweat Glands

Sweat Cl − is the gold standard for the diagnosis of CF; its limitations for diagnosis and monitoring the effects of CFTR-targeted drugs include “borderline” results and intra-subject variability [1]. CFTR-dependent sweating is induced by beta-adrenergic stimulation upon increased intracellular cAMP, w hereas CFTR-independent sweating is mediated by cholinergic stimulation that induces Ca²⁺-dependent Cl⁻ secretion [2]. Defective CFTR affects sweat production in response to beta-adrenergic stimulation.
Source: Journal of Cystic Fibrosis - Category: Respiratory Medicine Authors: Tags: Short Communication Source Type: research