Myeloproliferative neoplasm-driving Calr frameshift promotes the development of pulmonary hypertension in mice

Frameshifts in the Calreticulin (CALR) exon 9 provide a recurrent driver mutation of essential thrombocythemia (ET) and primary myelofibrosis among myeloproliferative neoplasms (MPNs). Here, we generated knock-in...

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-021-01064-8

Source: Journal of Hematology and Oncology - March 30, 2021 Category: Hematology Authors: Keiji Minakawa, Tetsuro Yokokawa, Koki Ueda, Osamu Nakajima, Tomofumi Misaka, Yusuke Kimishima, Kento Wada, Yusuke Tomita, Saori Miura, Yuka Sato, Kosaku Mimura, Koichi Sugimoto, Kazuhiko Nakazato, Kenneth E. Nollet, Kazuei Ogawa, Takayuki Ikezoe & hellip Tags: Letter to the Editor Source Type: research

More News: Cancer & Oncology | Hematology | Hypertension | Myeloproliferative Disorders | Pulmonary Hypertension