Stopping gene-regulating activity of signaling molecule could aid heart failure prevention

(Temple University Health System) Maladaptive growth of the heart is brought about in part by activation of GRK5, a signaling molecule found within heart cells that has been linked to worsened cardiac function in heart failure. Lewis Katz School of Medicine researchers now show for the first time in animals that keeping GRK5 out of the heart cell nucleus can block this abnormal growth process. The findings open avenues for the development of GRK5-based therapies to prevent heart failure.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news