Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency [RESEARCH ARTICLE]

In conclusion, the UOX-KO rat is a great model to study hyperuricemia-related diseases. Hyperuricemia-induced autophagy and NLRP3-dependent inflammation are critically involved in the development of renal damage and, therefore, highlight the inhibition of autophagy and inflammation in search of therapeutic strategies to treat uric acid nephropathy.

Source: DMM Disease Models and Mechanisms - March 24, 2021 Category: Biomedical Science Authors: Wu, M., Ma, Y., Chen, X., Liang, N., Qu, S., Chen, H. Tags: Rat as a Disease Model RESEARCH ARTICLE Source Type: research