Significant elevation of free itraconazole concentration at onset of adverse effects: A case report
Free itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects. AbstractFree itraconazole and hydroxyitraconazole concentrations were markedly elevated despite almost no changes in total concentrations when itraconazole was discontinued due to adverse effects. Elevated free itraconazole concentration may have a causal relationship with the development of adverse effects.
Source: Clinical Case Reports - Category: General Medicine Authors: Ryota Tanaka,
Yosuke Suzuki,
Hiroyuki Matsumoto,
Mari Yamasue,
Kenji Umeki,
Kazuhiko Hashinaga,
Ryosuke Tatsuta,
Kazufumi Hiramatsu,
Katsuhiko Kamei,
Jun ‐ichi Kadota,
Hiroki Itoh Tags: CASE REPORT Source Type: research
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