Global longitudinal strain predicts responders after cardiac resynchronization therapy —a systematic review and meta-analysis

AbstractTo evaluate the association between baseline global longitudinal strain (GLS) and ΔGLS (difference of baseline GLS and follow-up) and cardiac resynchronization therapy (CRT) response defined either with clinical or with echocardiographic characteristics. This meta-analysis was performed in accordance to both the Meta-Analysis of Observational Studies in Epidemiology and Strengt hening the Reporting of Observational Studies in Epidemiology guidelines. Two independent investigators performed a comprehensive systematic search in MedLine, EMBASE and Cochrane databases through September 2019 without limitations. Data analysis was performed by using the Review Manager software ( RevMan), version 5.3, and Stata 13 software. Ap value of less than 0.05 (two-tailed) was considered statistically significant.  Twelve studies (1004 patients, mean age 63.8 years old, males 69.4%) provided data on the association of baseline GLS with the response to CRT therapy. We found that CRT responders had significantly better resting GLS values compared with non-responders [GLS mean difference −2.13 (−3.03, −1 .23),p <  0.001,I2 78%]. Furthermore, CRT responders had significantly greater improvement of GLS at follow-up compared with non-responders [ ΔGLS mean difference −3.20 (−4.95, −1.45),p <  0.001,I2 66%]. These associations remained significant in a subgroup analysis including only studies with similar CRT response definition. In this meta-analysis, we found...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research