Identification of an individualized RNA binding protein ‐based prognostic signature for diffuse large B‐cell lymphoma

We found that six RNA binding proteins are significantly related to the overall survival of diffuse large B ‐cell lymphoma (DLBCL) patients, which could potentially be served as prognostic biomarkers. Gene Set Enrichment Analysis provided insight into the underlying mechanisms in the occurrence and development of DLBCL, which laid the foundation for further basic studies. AbstractRNA binding proteins (RBPs) are increasingly appreciated as being essential for normal hematopoiesis and have a critical role in the progression of hematological malignancies. However, their functional consequences and clinical significance in diffuse large B ‐cell lymphoma (DLBCL) remain unknown. Here, we conducted a systematic analysis to identify RBP‐related genes affecting DLBCL prognosis based on the Gene Expression Omnibus database. By univariate and multivariate Cox proportional hazards regression (CPHR) methods, six RBPs‐related genes (CMSS1,MAEL,THOC5,PSIP1,SNIP1, andZCCHC7) were identified closely related to the overall survival (OS) of DLBCL patients. The RBPs signature could efficiently distinguished low ‐risk from high‐risk patients and could serve as an independent and reliable factor for predicting OS. Moreover, Gene Set Enrichment Analysis revealed 17 significantly enriched pathways between high‐ versus low‐risk group, including the regulation of autophagy, chronic myeloid leukemia, NOTC H signaling pathway, and B cell receptor signaling pathway. Then we developed an R...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research