Group V Secretory Phospholipase A < sub > 2 < /sub > Regulates Endocytosis of Acetylated LDL by Transcriptional Activation of PGK1 in RAW264.7 Macrophage Cell Line

CONCLUSIONS: Nuclear sPLA2-V binds to the Pgk1 gene promoter region and increases its transcriptional activity. sPLA2-V regulates AcLDL endocytosis through PGK1-Beclin1 in a manner that is independent of its enzymatic activity in RAW264.7 cells.PMID:33775979 | DOI:10.5551/jat.62216
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Authors: Source Type: research