The role of two-component regulatory systems in environmental sensing and virulence in < em > Salmonella < /em >

We describe important aspects of these systems, such as the stimuli and responses involved, the processes regulated, and their roles in virulence. We also dissect the genomic organization of histidine kinases and response regulators, as well as the input and output domains for each TCS. Lastly, we explore how these systems may be promising targets for the development of antivirulence therapeutics to combat antibiotic-resistant infections.PMID:33751923 | DOI:10.1080/1040841X.2021.1895067

Source: Critical Reviews in Microbiology - March 22, 2021 Category: Microbiology Authors: Lucindo Cardoso de Pina Fernanda Stephens Hermes da Silva Teca Calcagno Galv ão Heidi Pauer Rosana Barreto Rocha Ferreira L Caetano M Antunes Source Type: research