Locomotor response to novelty correlates with differences in number and morphology of hypothalamic tyrosine hydroxylase positive cells in rats.

Locomotor response to novelty correlates with differences in number and morphology of hypothalamic tyrosine hydroxylase positive cells in rats. Brain Res Bull. 2014 Jan 3; Authors: Jerzemowska G, Plucińska K, Kuśmierczak M, Myślińska D, Orzeł-Gryglewska J Abstract Individual differences in the intensity of locomotor response to a new environment (exploratory reaction) are generally used as a model to study individual vulnerability to stress and drug addiction. In the present work we studied the number, distribution and morphology of the hypothalamic cells expressing tyrosine hydroxylase (TH+ cells) (immunohistochemical and immunofluorescent staining) in male Wistar rats divided based on high (HR), midline (MR) or low (LR) locomotor activity in response to novelty. Morphology and total number of TH+ cells were analyzed for A11-A15 dopaminergic groups. We found correlation between the total number of hypothalamic TH+ cells in the whole A11-A15 area and the locomotor activity. The differences were most pronounced in some of the hypothalamic nuclei, i.e. in the rostro-caudal extension of the A11, A12 and A14 structures, where the HR rats had a significantly higher number of TH+ cells in comparison to the MR and LR rats. Morphology analysis of TH+ cells showed HR/MR/LR differences in single cell area and perimeter and, to a lesser extent, in the other morphometric parameters such as length of the major and minor axes, or circularity factor. The results sugges...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research

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Conclusion and Significance: Understanding the participants' lived experiences raised consciousness of the injustices that exist before and during rehabilitation which uncovered pointers to improve local substance addiction rehabilitation programs: use of occupation-based social participation interventions, limitation of occupational therapy services due to lack of human resources reinforcing interprofessional collaboration, a participatory approach is essential in discussing and addressing injustices, and deliberate use of political activities of daily living. PMID: 31322976 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Authors: Mamun MA, Hossain MS, Siddique AB, Sikder MT, Kuss DJ, Griffiths MD Abstract Problematic Internet Use (PIU) has become a concern for public mental health across the globe. However, there are few studies assessing PIU in Bangladesh. The present cross-sectional study estimated the prevalence rate of PIU and its associated risk factors among 405 university students in Bangladesh between June and July 2018. The measures included sociodemographic questions, internet and health-related variables, the Internet Addiction Test (IAT) and the Depression, Anxiety and Stress Scale (DASS-21). The prevalence of PIU was 3...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
ConclusionThe report aims at pointing out the possibility of undergoing this kind of surgery not only in case of pulmonary mass (on which the previous literature has focused) but also when mediastinum lesions occur, as in our case.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Conclusions: Pretreatment characteristics differentially predict treatment response for heroin and cocaine use. Similar research in diverse patient groups may aid in the development of personalized treatment combining biologic treatment with targeted psychosocial interventions. PMID: 31315479 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Ever since I was diagnosed with bipolar disorder in 1991, I’ve struggled with my weight. At that time, I weighed 125 and was prescribed lithium to control my highs and lows. The drug worked, but it and other psychotropic drugs contributed to a 20-pound weight gain. Then, as the years went by, I gained the weight that comes with aging. By 40, I weighed about 180. On a 5’3″ frame, this was a lot to carry. I gained even more weight when I struggled with breast cancer in my late 40s and 50s. At 56, I weighed a cool 188 with no clothes on. Recently, I gained even more (I contribute this gain to simply overindu...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Anorexia Children and Teens Eating Disorders Habits Health-related Parenting Personal Adolescence Diet Food Addiction Lithium Weight Gain Source Type: blogs
In this study, we investigate the involvement of PFC DRD2 and DAT in ketamine addiction effects after ketamine administration for 10 weeks in nonhuman primates. To this end, after administering ketamine to rhesus monkeys for 10 weeks, we assessed changes in body weight and behavior. Additionally, neuronal changes in the PFC were examined by hematoxylin and eosin (HE) staining, the DRD2 and DAT mRNA and protein expression levels in the PFC were determined by real-time PCR and Western blot analysis, respectively. After 10-week ketamine administration, the assessment of the manifestations of toxicity in rhesus monkeys reveale...
Source: Neuroscience - Category: Neuroscience Source Type: research
This week’s Psychology Around the Net has the latest on a new virtual reality therapy trial for people diagnosed with serious mental illnesses, how people with mental health disorders are helping amend their descriptions in diagnostic guidelines, the issues that stop you from setting boundaries and how you can overcome those issues, and more. People With Mental Health Disorders Amend the Descriptions: What would happen if input from people who actually deal with mental health disorders on a daily basis was taken into consideration when it comes to the diagnostic guidelines describing said disorders? A new study set ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net Addiction Cannabis cannabis dependency cannabis treatment Loneliness Nhs Procrastination Productivity Psychosis Setting Boundaries Shame virtual reality Source Type: blogs
The objective of this document is to offer clinical guidance for screening, diagnosis and management of co-occurring betel quid chewing among persons with Diabetes Mellitus (DM). The document aims to provide education and guidance to clinicians engaged in care and management of persons with DM, and improve access to treatment for co-occurring betel quid chewing among persons with DM. The current recommendation grades are based on published evidence, and categorized as strong, intermediate, weak and no evidence. The strength of these recommendations is based on the level of evidence. PMID: 31315339 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
The rapid rise of electronic cigarette (e-cigarette) use among youth subverts our traditional understanding of adolescent tobacco use, the natural history of nicotine addiction through the use of combustible tobacco, and the implications of dual use of e-cigarettes and combustible cigarettes. The ramifications of initiating tobacco use with nicotine vapor in adolescence are largely unknown, as are the appropriate classifications of adolescent tobacco users in the e-cigarette era or means to identify the populations most likely to benefit from nicotine cessation strategies.
Source: Journal of Adolescent Health - Category: Child Development Authors: Tags: Editorial Source Type: research
We examined factors associated with reporting sex with men among men who inject drugs in Vancouver, Canada. Data were drawn from three open prospective cohorts of people who use drugs between 2005 and 2014. Generalized estimating equations were used to identify factors associated with reporting non-transactional sex with men (MSM) in the previous 6  months. Of 1663 men who used injection drugs, 225 (13.5%) were MSM over the study period. Sex with men was independently associated with younger age [Adjusted Odds Ratio (AOR) = 0.96], childhood sexual abuse (AOR = 2.65), sex work (AOR =&...
Source: AIDS and Behavior - Category: Infectious Diseases Source Type: research
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