Acute effect of a single session of lipoprotein apheresis on central haemodynamics in patients with familial hypercholesterolaemia

To the Editor, We read with interest the paper by Pottle et al. demonstrating a 62.5% reduction in major adverse cardiovascular events following introduction of lipoprotein apheresis (LA)1. Previous work has shown that LA results in improvements in coronary and peripheral vasomotor function, which may, in part account for the associated improvements in clinical outcomes, alongside the reduction in atherogenic ApoB-containing particles2, 3. However, pulse wave velocity (PWV) and augmentation index (AIx) appear unchanged post-LA4, 5, but its influence on other cardiovascular physiological biomarkers is less well known.
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Correspondence Source Type: research