Impact of metformin on clinical outcomes among men with prostate cancer: a systematic review and meta-analysis

Impact of metformin on clinical outcomes among men with prostate cancer: a systematic review and meta-analysis Prostate Cancer and Prostatic Diseases advance online publication, February 10 2015. doi:10.1038/pcan.2014.52 Authors: A D Raval, D Thakker, A Vyas, M Salkini, S Madhavan &U Sambamoorthi
Source: Prostate Cancer and Prostatic Diseases - Category: Urology & Nephrology Authors: Source Type: research

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AbstractMen treated for prostate cancer with curative intent face a recurrence rate of up to 53% at 10  years.68Ga-PSMA imaging is a new technique that can more accurately stage cancer recurrences and facilitate personalised treatment. We evaluated the cost-effectiveness of68Ga-PSMA PET/MRI for staging men with prostate cancer biochemical recurrence. A cost-effectiveness analysis using a decision-analytic model with Markov chains was constructed.68Ga-PSMA PET/MRI was compared with usual care in staging of men with suspected prostate cancer recurrence. Men with biochemical recurrence from a study in Brisbane, Australia...
Source: Clinical and Experimental Metastasis - Category: Cancer & Oncology Source Type: research
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Source: Journal of Psychosocial Oncology - Category: Cancer & Oncology Authors: Source Type: research
Despite good prognosis, increased suicide rates are reported for prostate cancer. The aim of this study was to assess the risk of suicide among prostate cancer patients before and after the start of nation-wide prostate-specific antigen (PSA)-based screeni...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
CONCLUSION: Surgeon's personal experiences has a significant impact on the decision-making processes during preoperative assessments. However, non-patient factors such as institutional microcultures passively and actively influence decision-making process during preoperative assessment. PMID: 31872469 [PubMed - indexed for MEDLINE]
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: J Surg Oncol Source Type: research
AbstractObjectivesConventional spin-echo (SE) DWI leads to a fundamental trade-off depending on theb value: highb value provides better lesion contrast-to-noise ratio (CNR) by sacrificing signal-to-noise ratio (SNR), image quality, and quantitative reliability. A stimulated-echo (STE) DWI acquisition is evaluated for high-CNR imaging of prostate cancer while maintaining SNR and reliable apparent diffusion coefficient (ADC) mapping.MethodsIn this prospective, IRB-approved study, 27 patients with suspected prostate cancer (PCa) were scanned with three DWI sequences (SEb = 800 s/mm2, SEb = 150...
Source: European Radiology - Category: Radiology Source Type: research
An increasing number of men diagnosed with localised prostate cancer has been accompanied by more men being considered for active surveillance as a management option. Here the author provides an update on recent developments in active surveillance and changes to NICE guidance.
Source: Trends in Urology and Men's Health - Category: Urology & Nephrology Authors: Tags: Prostate disease Source Type: research
Publication date: Available online 14 February 2020Source: European UrologyAuthor(s): Maria Chiara Sighinolfi, Bernardo Rocco
Source: European Urology - Category: Urology & Nephrology Source Type: research
This study included 74 Japanese patients with CRPC who were treated with cabazitaxel between 2014 and 2017. Associations between clinicopathological factors including serum markers and progression-free survival (PFS) and overall survival (OS) were investigated. On multivariate analysis, high Gleason score [≥9 vs. ≤7; hazard ratio (HR), 95% confidence interval (CI): 2.00 (1.01–4.34); P = 0.047], presence of pain [HR, 95% CI: 2.02 (1.14–3.58); P = 0.016], and lactate dehydrogenase (LDH) level [HR, 95% CI: 47.31 (3.79–577.49); P = 0.0019] were significantly associated with PFS. Similarly, number of doc...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Clinical Reports Source Type: research
This study is the first examining the interplay between Slit2 –Robo1–CXCR4 proteins and silymarin in DU145 cells. We believe that our study will provide new insights for future studies.
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
The study couldn't prove cause and effect, but it found that statins, taken alone or with metformin, did seem associated with an increase in survival.
Source: WebMD Health - Category: Consumer Health News Source Type: news
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