Altered Endocytosis in Cellular Senescence

Ageing Res Rev. 2021 Mar 19:101332. doi: 10.1016/j.arr.2021.101332. Online ahead of print.ABSTRACTCellular senescence occurs in response to diverse stresses (e.g., telomere shortening, DNA damage, oxidative stress, oncogene activation). A growing body of evidence indicates that alterations in multiple components of endocytic pathways contribute to cellular senescence. Clathrin-mediated endocytosis (CME) and caveolae-mediated endocytosis (CavME) represent major types of endocytosis that are implicated in senescence. More recent research has also identified a chromatin modifier and tumor suppressor that contributes to the induction of senescence via altered endocytosis. Here, molecular regulators of aberrant endocytosis-induced senescence are reviewed and discussed in context of their capacity to serve as senescence-inducing stressors or modifiers.PMID:33753287 | DOI:10.1016/j.arr.2021.101332

Source: Ageing Research Reviews - March 23, 2021 Category: Genetics & Stem Cells Authors: Eun-Young Shin Nak-Kyun Soung Martin Alexander Schwartz Eung-Gook Kim Source Type: research