Liver type 1 innate lymphoid cells develop locally via an interferon-{gamma}-dependent loop

The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains Lin–Sca-1+Mac-1+ hematopoietic stem cells derived from the fetal liver. This population includes Lin–CD122+CD49a+ progenitors that can generate liver ILC1s but not conventional natural killer cells. Interferon- (IFN-) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-R+ liver progenitors. Thus, an IFN-–dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver.

Source: ScienceNOW - March 25, 2021 Category: Science Authors: Bai, L., Vienne, M., Tang, L., Kerdiles, Y., Etiennot, M., Escaliere, B., Galluso, J., Wei, H., Sun, R., Vivier, E., Peng, H., Tian, Z. Tags: Immunology, Online Only r-articles Source Type: news