Primer for development of guidelines for helicobacter pylori therapy using antibiotic stewardship

We provide a primer to assist in the difficult transition of Helicobacter pylori therapy guidelines to those that adhere to the principles of antimicrobial stewardship. This transition will entail abandonment of many of the principles that heretofore formed the basis of treatment guidelines and recommendations. The goals of antimicrobial stewardship include optimization of the use of antibiotics while reducing antimicrobial resistance. The critical outcome measure is absolute cure rate which largely restricts comparative trials to those which reliably produce high cure rates (e.g., ∼95%).
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research