Ectyoplasin, a novel cytotoxic cyclic peptide from < em > Ectyoplasia ferox < /em > sponge

Nat Prod Res. 2021 Mar 22:1-9. doi: 10.1080/14786419.2021.1902326. Online ahead of print.ABSTRACTA new cyclic heptapeptide, ectyoplasin (1), was isolated from a methanol extract of the sponge Ectyoplasia ferox. The planar structure of 1, cyclo(-Leu1-Asn2-Ala3-Val4-Thr5-Pro6-Gly7-), was determined by one and two-dimensional NMR spectroscopy and high-resolution tandem mass spectrometry. Its absolute stereochemistry was solved by Marfey's method. The in vitro assays show that ectyoplasin (1) possess significant cytotoxic activity (2.9 - 23.5 µM) against the cell lines, DU-145 (human prostate cancer), Jurkat (human T-cell acute leukaemia), MM144 (human multiple myeloma), HeLa (human cervical carcinoma) and CADO-ES1 (human Ewing's sarcoma). The DU-145 cell line showed apoptotic cell death in response to ectyoplasin (1) treatment.PMID:33749445 | DOI:10.1080/14786419.2021.1902326
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research