Role of adiponectin and free fatty acids on the association between abdominal visceral fat and insulin resistance

Background: Experimental studies have shown that high free fatty acid (FFA) and low adiponectin (ADIPO) levels are involved in the mechanisms by which adiposity promotes insulin resistance (IR). However, no previous clinical studies have simultaneously analysed the relative contribution of FFA and ADIPO levels on the relation of abdominal visceral fat (AVF) with insulin resistance.ObjectiveTo analyse the contribution of low ADIPO (adiponectin??=p75th: 0.745?mEq/L in women and 0.60?mEq/L in men) to the association of high AVF (AVF?>?=p75th: 127?cm2 in women; 152.7?cm2 in men) with insulin resistance (HOMA-IR?>?=75th: 3.58 in women and 3.12 in men), in non-diabetic subjects.Material and methodsA cross-sectional analysis was performed including 1217 control participants of the Genetics of Atherosclerotic Disease study (GEA). Clinical, tomographic and biochemical parameters were measured in all participants. Logistic regression models were used to assess the association of high AVF with IR stratifying according to gender, and to normal or low ADIPO and normal or high FFA serum levels. Results: In comparison to referent group, in men low ADIPO unlike high FFA increased the risk of IR. Females with normal AVF and low ADIPO, or high AVF and normal ADIPO had aprox 3 folds risk of IR (OR [IC95%]: 3.7 [2.1-6.6], p?
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research