Measurement of multiple cytokines for discrimination and risk stratification in patients with Chagas ’ disease and idiopathic dilated cardiomyopathy

by Yong Wang, Niels Wessel, Franziska Kohse, Adnan Khan, Heinz-Peter Schultheiss, Maria da Consola ҫão V. Moreira, Thomas Walther Chagas’ disease (CD), caused by the hemoflagellate protozoan,Trypanosoma cruzi, is endemic in most countries of Latin America. Heart failure (HF) is often a late manifestation of chronic CD, and is associated with high morbidity and mortality. Inflammatory processes mediated by cytokines play a key role in the pathogenesis and progression of CD. Keeping in view the inflammatory nature of CD, this study investigated the possible role of 21 different inflammatory cytokines as biomarkers for prediction and prognosis of CD. The plasma concentration of these cytokines was measured in a group of patients with CD (n = 94), and then compared with those measured in patients with dilated cardiomyopathy (DCM) from idiopathic causes (n = 48), and with control subjects (n = 25). Monovariately, plasma levels of cytokines such as stem cell growth factor beta (SCGF beta), hepatocyte growth factor (HGF), monokine induced by interferon gamma (CXCL9), and macrophage inhibitory factor (MIF) were significantly increased in CD patients with advanced HF compared to control group. None of the cytokines could demonstrate any prognostic potency in CD patients, and only MIF and stromal derived factor-1 alpha (CXCL12) showed significance in predicting mortality and necessity for heart transplant in DCM patients. However, multivariate analysis prognosticated a large propo...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research