Oxylipin patterns in human colon adenomas

Colorectal carcinoma (CRC) is the third most commonly diagnosed cancer worldwide [1]. Alteration in lipid metabolism is a hallmark of cancer [2]. In the context of CRC development a pro-tumorigenic role for prostaglandin E2 (PGE2) is well established and downstream signaling pathways for PGE2-mediated pro-tumorigenic effects were identified [3-5]. Despite a lack of large randomized prospective trials, numerous epidemiological and observational studies show that long-term low-dose acetylsalicylic acid (ASA) intake reduces the incidence of CRC and that even post-CRC-diagnosis ASA therapy exerts positive effects on CRC overall survival [6, 7].

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 23, 2021 Category: Biomedical Science Authors: Christoph Schm öcker, Heike Gottschall, Katharina M. Rund, Laura Kutzner, Fabian Nolte, Annika I. Ostermann, Dirk Hartmann, Nils Helge Schebb, Karsten H. Weylandt Source Type: research