Association between BRCA2 alterations and intraductal and cribriform histologies in prostate cancer

Intraductal (IDC) and cribriform (CRIB) histologies in prostate cancer have been associated with germline BRCA2 (gBRCA2) mutations in small retrospective series, leading to the recommendation of genetic testing for patients with IDC in the primary tumour.

Source: European Journal of Cancer - February 21, 2021 Category: Cancer & Oncology Authors: Rebeca Lozano, Daniela C. Salles, Shahneen Sandhu, Isabel M. Arag ón, Heather Thorne, Fernando López-Campos, José Rubio-Briones, Ana M. Gutierrez-Pecharroman, Laneisha Maldonado, Tomas di Domenico, Alejandro Sanz, Juan D. Prieto, Isabel García, María Tags: Original Research Source Type: research