Dynamics of leucocyte DNA thioguanine nucleotide levels during maintenance therapy of childhood acute lymphoblastic leukemia

ConclusionFluctuations in DNA-TGTotal are predominantly caused by corresponding fluctuations in DNA-TGPMN, thus DNA-TGTotal measures recent TGN incorporation in these short-lived cells. Measurement of DNA-TGTotal at 2 –4 weeks intervals provides a reliable profile of DNA-TG levels.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research