Retinoblastoma cell-derived Twist protein promotes regulatory T cell development

ConclusionsRbcs express Twist, that induces IL-4+ Foxp3+ Tregs; the latter can inhibit CD8+ cytotoxic T cell activities. Therefore, Twist may play an important role in the pathogenesis of Rb.

Source: Cancer Immunology, Immunotherapy - March 20, 2021 Category: Cancer & Oncology Source Type: research