Parasites may make dogs smell good to insect vector

(PLOS) The protist parasite Leishmania infantum can alter its host's odor to attract female sand flies, which transmit the pathogen, according to a study published March 18th in the open-access journal PLOS Pathogens by Monica Staniek of Lancaster University and Gordon Hamilton of Lancaster University.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Immune metabolic adaptation in macrophages by intracellular parasites is recognized to play a crucial role during Leishmania infection. However, there is little accessible information about changes in a metabolic switch in L. donovani infected macrophages. In previous studies, we have reported on the anti-leishmanial synergic effect of eugenol oleate with amphotericin B. In the present study, we demonstrated that glycolytic enzymes were highly expressed in infected macrophages during combinatorial treatment of eugenol oleate (2.5 µM) and amphotericin B (0.3125 µM). Additionally, we found that the biphasic role ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Int J Parasitol. 2021 Jul 27:S0020-7519(21)00233-2. doi: 10.1016/j.ijpara.2021.05.009. Online ahead of print.ABSTRACTLeishmania (Leishmania) major is an important agent of cutaneous leishmaniasis, having as a vector sandflies belonging to the genus Phlebotomus. Although this species has been described as restricted to the Old World, parasites similar to L. major have been isolated from South American patients who have never traveled abroad. These parasites were named "L. major-like", and several studies have been carried out to characterize them biochemically, molecularly, and biologically. However, the phylogene...
Source: International Journal for Parasitology - Category: Parasitology Authors: Source Type: research
Bioorg Chem. 2021 Jul 2;114:105141. doi: 10.1016/j.bioorg.2021.105141. Online ahead of print.ABSTRACTA new series of 3-aryl-4-(N-aryl)aminocoumarins was synthesized in two steps starting from the natural product 4-hydroxycoumarin using the photoredox catalysis for the key step. These conditions reactions allowed to make CC bonds is up to 95% yields in mild conditions, easy operation, in an environmentally benign way, and are compatible with several patterns of substitution. The biological activity of the new compounds was tested in vitro against MCF-7, MDA-MB-231, and CCD-1072Sk cancer cell lines, as soon as to promastigot...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research
Int J Parasitol. 2021 Jul 27:S0020-7519(21)00233-2. doi: 10.1016/j.ijpara.2021.05.009. Online ahead of print.ABSTRACTLeishmania (Leishmania) major is an important agent of cutaneous leishmaniasis, having as a vector sandflies belonging to the genus Phlebotomus. Although this species has been described as restricted to the Old World, parasites similar to L. major have been isolated from South American patients who have never traveled abroad. These parasites were named "L. major-like", and several studies have been carried out to characterize them biochemically, molecularly, and biologically. However, the phylogene...
Source: International Journal for Parasitology - Category: Parasitology Authors: Source Type: research
Bioorg Chem. 2021 Jul 2;114:105141. doi: 10.1016/j.bioorg.2021.105141. Online ahead of print.ABSTRACTA new series of 3-aryl-4-(N-aryl)aminocoumarins was synthesized in two steps starting from the natural product 4-hydroxycoumarin using the photoredox catalysis for the key step. These conditions reactions allowed to make CC bonds is up to 95% yields in mild conditions, easy operation, in an environmentally benign way, and are compatible with several patterns of substitution. The biological activity of the new compounds was tested in vitro against MCF-7, MDA-MB-231, and CCD-1072Sk cancer cell lines, as soon as to promastigot...
Source: Bioorganic Chemistry - Category: Chemistry Authors: Source Type: research
Biomed Pharmacother. 2021 Jul 20;141:111920. doi: 10.1016/j.biopha.2021.111920. Online ahead of print.ABSTRACTThe study of tropical diseases like leishmaniasis, a parasitic disease, has not received much attention even though it is the second-largest infectious disease after malaria. As per the WHO report, a total of 0.7-1.0 million new leishmaniasis cases, which are spread by 23 Leishmania species in more than 98 countries, are estimated with an alarming 26,000-65,000 death toll every year. Lack of potential vaccines along with the cost and toxicity of amphotericin B (AmB), the most common drug for the treatment of leishm...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
apanastasiou The protozoan diseases Human African Trypanosomiasis (HAT), Chagas disease (CD), and leishmaniases span worldwide and therefore their impact is a universal concern. The present regimen against kinetoplastid protozoan infections is poor and insufficient. Target-based design expands the horizon of drug design and development and offers novel chemical entities and potential drug candidates to the therapeutic arsenal against the aforementioned neglected diseases. In this review, we report the most promising targets of the main kinetoplastid parasites, as well as their corresponding inhibitors. This overview is...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
In conclusion, data suggest that derivative 4 presents selective antileishmanial effect, which is associated with multi-target action, and can be considered for future studies for the treatment against disease.PMID:34323702 | DOI:10.1016/j.biopha.2021.111857
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
Pathophysiology of visceral leishmaniasis (VL) is not fully understood and it has been widely accepted that the parasitic components and host immune response both contribute to the perpetuation of the disease. Host alterations during leishmaniasis is a feebly touched area that needs to be explored more to better understand the VL prognosis and diagnosis, which are vital to reduce mortality and post-infection sequelae. To address this, we performed untargeted metabolomics of Leishmania donovani (Ld) infected, uninfected and treated BALB/c mice’s tissues and biofluids to elucidate the host metabolome changes using gas ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Leishmania infantum and Dirofilaria immitis are among the most important canine vector-borne pathogens (CVBPs) of zoonotic concern in Europe. In endemic areas for both of these CVBPs, the use of systemic ectopar...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
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