The Potential Role of Pancreatic γ‑Aminobutyric Acid (GABA) in Diabetes Mellitus: A Critical Reappraisal

Conclusions: Pancreatic GABA improves islet cell function, glucose homeostasis, and autoimmunity in DM. Orally administered GABA is safe for humans, and acts on peripheral GABA receptors and represents a new therapeutic modality for both T1DM and T2DM. Besides, GABA ‑A receptor agonist like benzodiazepines improves pancreatic β‑cell function and insulin sensitivity through activation of GABA‑A receptors.
Source: International Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research