Prevalence and risk factors for high-frequency basal cell carcinoma in the United States
To the Editor: Rare genetic diseases such as basal cell nevus syndrome (BCNS) or Gorlin syndrome are known to predispose patients to early-onset, high-frequency basal cell carcinoma (HF-BCC).1 However, there are patients who develop unusually frequent BCCs but who do not harbor germline mutations in PTCH1 or SUFU or meet the clinical phenotypes of known genetic syndromes. A retrospective study of patients with BCC at Stanford evaluated with genetic testing and pathology found that among patients with nonsyndromic BCC monitored for 5 to 10 years, 3% of patients developed 9 or more BCCs.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Audris Chiang, Daniel C. Solis, Howard Rogers, Grace K. Sohn, Hyunje G. Cho, Gillian Saldanha, David Lapidus, Shufeng Li, Kavita Y. Sarin, Jean Y. Tang Tags: Letter Source Type: research
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