Waist circumference and a body shape index and prostate cancer risk and mortality

This study provides a more complete picture of the association between abdominal adiposity and the risk of prostate cancer and the mortality associated with it. The findings support a prevailing, yet poorly tested, hypothesis that the negative association between waist circumference and the risk of localised prostate cancer may be partly driven by normal ‐weight men undergoing prostate cancer screening more often than obese men. The negative association between waist circumference and the risk of localised prostate cancer is partially driven by asymptomatic prostate cancer’s detected through a prostate‐specific antigen test. AbstractWe recently found a negative association between body mass index (BMI) and the risk of localised prostate cancer (PCa), no association with advanced PCa, and a positive association with PCa ‐specific mortality. In a 15% subpopulation of that study, we here investigated the measures of abdominal adiposity including waist circumference (WC) and A Body Shape Index (ABSI) in relation to PCa risk and mortality. We used data from 58,457 men from four Swedish cohorts to assess WC and ABSI i n relation to PCa risk according to cancer risk category, including localised asymptomatic and symptomatic PCa and advanced PCa, and PCa‐specific mortality. Cox regression models were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). During, on average, 10 years of follow‐ up, 3290 men were diagnosed with PCa and 387 died of PCa. W...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research