Molecular differential analysis of uterine leiomyomas and leiomyosarcomas through weighted gene network and pathway tracing approaches

This study provides vital clues for molecular distinction of UL and ULMS which could further assist in identification of specific diagnostic markers and therapeutic targets.Abbreviations UL: Uterine Leiomyomas; ULMS: Uterine Leiomyosarcoma; Myo: Myometrium; DEGs: Differential Expressed Genes; RMA: Robust Multiarray Average; DC: Degree of Centrality; BC: Betweenness of Centrality; CGC: Cancer Gene Census; FDR: False Discovery Rate; TCGA: Cancer Genome Atlas; BP: Biological Process; CC: Cellular Components; MF: Molecular Function; PPI: Protein-Protein Interaction.PMID:33685300 | DOI:10.1080/19396368.2021.1876179

Source: Systems Biology in Reproductive Medicine - March 9, 2021 Category: Reproduction Medicine Authors: Nora Naif Sahly Babajan Banaganapalli Ahmed N Sahly Ali H Aligiraigri Khalidah K Nasser Thoraia Shinawi Arif Mohammed Abdulhakeem S Alamri Nabeel Bondagji Ramu Elango Noor Ahmad Shaik Source Type: research