Bone and joint infections caused by Clostridium perfringens: a case series

The objective of this study was to evaluate antimicrobial therapy outcomes of bone and joint infections (BJI) caused byClostridium perfringens. We investigated remission of symptoms and the absence of relapse or reinfection during follow-up. Among the 8 patients withC. perfringens BJI, the type of infection was early prosthesis infection (n = 2), osteosynthetic device infection (n = 4), and chronic osteomyeletis (n = 2). Clindamycin-rifampicin combination was given in 4 cases and metronidazole in 4 cases. The overall success rate was 87.5%. Among the 7 patients who completed antibiotic treatment, the success rate was 100%. The clindamycin-rifampicin combination appeared to be effective in patients withC. perfringens BJI.
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research