Kidney biopsy findings in vancomycin-induced acute kidney injury: a pooled analysis

ConclusionsAcute tubular necrosis and tubulointerstitial nephritis represent the main histological patterns of vancomycin-induced acute kidney injury. The presence of fibrosis in the context of interstitial inflammation may be linked to lower recovery rates and worse long-term renal outcomes. A novel cast nephropathy obstructive mechanism has been suggested, necessitating further confirmation. Large-scale studies should define the exact indications of kidney biopsy in cases with suspected vancomycin nephrotoxicity.
Source: International Urology and Nephrology - Category: Urology & Nephrology Source Type: research