Exercise alters Cardiac Function Independent of Acute Systemic Inflammation in Healthy Men

Am J Physiol Heart Circ Physiol. 2021 Mar 12. doi: 10.1152/ajpheart.00809.2020. Online ahead of print.ABSTRACTAcute elevations in inflammatory cytokines have been demonstrated to increase aortic and left ventricular stiffness and reduce endothelial function in healthy subjects. As vascular and cardiac function are often transiently reduced following prolonged exercise, it is possible that cytokines released during exercise may contribute to these alterations. The a priori aims of this study were to determine if vaccine-induced increases in inflammatory-cytokines would reduce vascular and left ventricular function, whether vascular alterations would drive cardiac impairments, and whether this would be potentiated by moderate exercise. In a randomized cross-over fashion, sixteen male participants were tested under control (CON) and inflammatory (INF) conditions, wherein INF testing occurred 8h following administration of an influenza vaccine. On both days, participants underwent measures of echocardiography performed during light cycling (stress-echocardiography), carotid-femoral pulse wave velocity (cf-PWV), and superficial femoral flow-mediated dilation (FMD) before and after cycling for 90min at ~85% of their first ventilatory threshold. IL-6 increased significantly (∆1.9±1.3pg/mL, P<0.001), while TNFα was non-significantly augmented (∆0.05±0.11pg/mL, P=0.09), 8h following vaccination. Vascular function was unaltered following cycling or inflammation (all P>0.05...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Source Type: research