TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features

ConclusionOur study showsTERT-p mutations are the most frequent somatic mutations in penile SCC. In addition,TERT-p mutations are far more frequent in non-HPV-related penile SCC than in HPV-related penile SCC, indicatingTERT-p mutations may have a role in tumorigenesis distinct from HPV-related penile SCC.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research