Treatment Practices and Outcomes in Continuous Spike and Wave during Slow Wave Sleep: A Multicenter Collaboration

To determine how continuous spike and wave during slow wave sleep (CSWS) is currently managed and to compare the effectiveness of current treatment strategies using a database from 11 pediatric epilepsy centers in the US.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Original Articles Source Type: research

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Abstract T-type calcium channels are low-threshold voltage-gated calcium channel and characterized by unique electrophysiological properties such as fast inactivation and slow deactivation kinetics. All subtypes of T-type calcium channel (Cav3.1, 3.2 and 3.3) are widely expressed in the central nerve system, and they have an important role in homeostasis of sleep, pain response, and development of epilepsy. Recently, several reports suggest that T-type calcium channels may mediate neuronal plasticity in the mouse brain. We succeeded to develop T-type calcium channel enhancer ethyl 8'-methyl-2',4-dioxo-2-(piperidin...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
Conditions:   Rolandic Epilepsy;   Rolandic Epilepsy, Benign;   Centrotemporal Epilepsy;   Centrotemporal; EEG Spikes, Epilepsy of Childhood;   Epilepsy; Seizure;   Epilepsy Intervention:   Other: Auditory stimulation Sponsors:   Massachusetts General Hospital;   Boston University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
TUESDAY, Sept. 29, 2020 -- Patients with generalized epilepsy have a higher risk for obstructive sleep apnea (OSA), according to a study published in the October issue of Epilepsy&Behavior. Matthew T. Scharf, M.D., from Rutgers-Robert Wood...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(Rutgers University) People with generalized epilepsy who have seizures arising from both sides of the brain simultaneously, have a higher risk of obstructive sleep apnea (OSA) compared to patients who have focal epilepsy where seizures emanate from one area of the brain, according to a Rutgers study.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 25 September 2020Source: SeizureAuthor(s): Ranjith Kumar Manokaran, Manjari Tripathi, Biswaroop Chakrabarty, Ravindra Mohan Pandey, Sheffali Gulati
Source: Seizure - Category: Neurology Source Type: research
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
Incidental centrotemporal (rolandic) spikes frequently appear on electroencephalograms (EEGs) of school-age and preschool-age children. Among the patients undergoing EEGs at the Children ’s Hospital of Nanjing Medical University from 2015 to 2018, 10.8% showed incidental rolandic spikes. Rolandic epilepsy (RE) is characterized by focal seizures and interictal rolandic spikes on EEG during sleep.
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
ConclusionThis case report provides evidence that a lower than previously reported dose of a phytocannabinoid in the form of a cannabidiol-based extract may be capable of aiding in autism spectrum disorder-related behavioral symptoms, core social communication abilities, and comorbid anxiety, sleep difficulties, and weight control. Further research is needed to elucidate the clinical role and underlying biological mechanisms of action of cannabidiol-based extract in patients with autism spectrum disorder.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Publication date: November 2020Source: Epilepsy &Behavior, Volume 112Author(s): Matthew Stauder, Andre C. Vogel, Damber K. Nirola, Lhab Tshering, Ugyen Dema, Chencho Dorji, Lhab Dorji, Farrah J. Mateen, Bhutan Epilepsy Project
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
In conclusion, the information obtained from the analysis of classical macro EEG contacts can be complemented by the one of micro wire EEG recordings. This combined approach may therefore help to further improve the degree to which quantitative EEG analysis can contribute to the diagnostics in epilepsy patients.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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