NAFLD, Insulin Resistance, and Diabetes Mellitus Type 2

Can J Gastroenterol Hepatol. 2021 Feb 17;2021:6613827. doi: 10.1155/2021/6613827. eCollection 2021.ABSTRACTNonalcoholic fatty liver disease is a condition defined by fat accumulation in hepatocytes not promoted by excessive alcohol consumption. It is highly prevalent and is strongly associated with insulin resistance, metabolic syndrome, and diabetes type II. Insulin resistance plays a crucial role in the multifactorial etiopathogenesis of this condition leading to accumulation of free fatty acids in the liver cells, thus causing lipotoxicity, inflammation, and fibrosis. In this review, we will focus on currently known pathogenesis of nonalcoholic fatty liver disease. Numerous investigation strategies are available to establish the diagnosis, from biochemical markers and ultrasound to various molecular and advanced imaging techniques and liver biopsy. Prevention is crucial. However, effective and promising therapies are strongly demanded.PMID:33681089 | PMC:PMC7904371 | DOI:10.1155/2021/6613827
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research