Implication of efflux pumps and < em > ERG11 < /em > genes in resistance of clinical < em > Trichosporon asahii < /em > isolates to fluconazole

Conclusion. T. asahii FCZ resistance mechanisms are proven to be much more complex and gene alteration sequence and/or expression can be involved. Only Mdr gene over-expression was significantly associated with FCZ resistance and no good correlation was observed between FCZ and VCZ MIC values and relative gene expression. ERG11 sequence alteration seems to play a major role in T. asahii FCZ resistance mechanism but their involvement needs further confirmation.PMID:33688802 | DOI:10.1099/jmm.0.001236
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research