Systematic review of lung shunt fraction quantification comparing SPECT/CT and planar scintigraphy for yttrium 90 radioembolization planning

ConclusionThe current clinical assessment of LSF is substantially overestimated by 2D planar scintigraphy when compared to 3D SPECT/CT. However, unclearness of blinding between the index test and reference standard was an area of quality concern. Hence, further randomized or prospective studies are needed to strengthen the role of SPECT/CT in lung shunt fraction estimation.
Source: Clinical and Translational Imaging - Category: Radiology Source Type: research