Congenital Heart Disease and Myelomeningocele in the Newborn: Prevalence and Mortality

AbstractMyelomeningocele (MMC) and congenital heart disease (CHD) are independent risk factors for increased morbidity and mortality in the newborn period and each can require significant operations shortly after birth. Few studies have examined the impact of these combined lesions. We sought to examine the incidence of CHD in patients with MMC, and to evaluate length of stay (LOS), hospital charges, and mortality. Using the Texas Inpatient Public Use Data File,  ~ 6.9 million newborn records between 1/1999 and 12/2016 were examined. Hospitalizations were classified as MMC without CHD (n = 3054), CHD without MMC (n = 72,266), and MMC with CHD (n = 171). The birth prevalence of CHD with MMC was 0.3/10,000 live hospital births, with 5% of patients with MMC having CHD, and 0.2% of those with CHD having MMC. There was increased LOS in patients with both MMC and CHD (median 15 days, IQR 5–31), compared to CHD without MMC (median 6 days, IQR 2–20) and MMC without CHD (median 8 days, IQR 1–14) and higher total hospital charges (median $95,007, IQR $26,731–$222,660) compared to CHD without MMC (median $27,726, $6463–$118,370) and MMC without CHD (median $40,066, IQR $5744–$97,490). Mortality was significantly higher in pat ients with MMC and CHD (22.2% compared to 3.1% in MMC without CHD and 4.1% in CHD without MMC). Significance remained when limiting for patients without genetic conditions or additional major birth defects. MMC with CHD in the newborn...
Source: Pediatric Cardiology - Category: Cardiology Source Type: research