High-fat diet induces follicular hyperkeratinization and predisposes to develop neutrophilic folliculitis in mice

Neutrophilic folliculitis is an inflammatory condition of hair follicles. In some neutrophilic folliculitis, such as acne and hidradenitis suppurativa, follicular hyperkeratosis is also observed. Neutrophilic folliculitis is often induced and/or exacerbated by high-fat diet (HFD). However, the molecular mechanisms by which HFD affects neutrophilic folliculitis are not fully understood.

Source: Journal of Allergy and Clinical Immunology - March 10, 2021 Category: Allergy & Immunology Authors: Satoshi Nakamizo, Tetsuya Honda, Tomohito Sato, Md. Al Mamun, Zachary Chow, Kaibo Duan, Josephine Lum, Kahbing Jasmine Tan, Kaori Tomari, Reiko Sato, Akihiko Kitoh, Angeline S.L. Tay, John E.A. Common, Ng Lai Guan, Mitsutoshi Setou, Florent Ginhoux, Kenji Source Type: research